Zaleplon has a longer duration of action therefore is better suited for patients that not only have problems falling asleep but also have problems staying asleep. Zolpidem titrate however, is better suited for patients that have issues falling asleep. The duration of action of zolpidem titrate is only 2-3 hours therefore has a low risk of next day drowsiness.
For more information on the sleep hygiene and all the above mentioned medications please refer to the following links:
1) Healthy Sleep Tips - http://sleepfoundation.org/sleep-tools-tips/healthy-sleep-tips
2) Melatonin- http://www.webmd.com/vitamins-supplements/ingredientmono-940-melatonin.aspx?activeingredientid=940&activeingredientname=melatonin
3) Diphenhydramine- http://www.webmd.com/drugs/2/drug-63760/sleep-aid-diphenhydramine-oral/details
4) Zaleplon- http://www.webmd.com/drugs/2/drug-17524/zaleplon-oral/details
5) Zolpidem Tartrate- http://www.webmd.com/drugs/2/drug-8862-466/zolpidem-6)oral/zolpidemextended-release-oral/details
Posted by Parisa Karimi, PharmD 2015